1st - 5th June 2015, Grenoble

Molecular Interactions: the complementarity between biophysical methods

The aim of the course is to provide theoretical, practical and data analysis training in five modern methods for monitoring and quantifying molecular interactions – SEC-MALS, analytical ultracentrifugation, surface plasmon resonance, isothermal titration calorimetry and microscale thermophoresis. The course will provide brief theoretical introduction to the biophysical concepts underlying these methods, practicalities to prepare samples and set-up experiments, experimental demonstrations performed on state-of-art instruments present in the PSB platform on the EPN campus, introduction to basic and advanced data analysis methods. The proposed course will put emphasis on the complementary of these different methods in the field of macromolecular biology and on the combined analysis of datasets coming from different methods. The main outcome expected from the course will be the ability for the participants to define and perform the appropriate experiments for the purpose of a particular project.

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